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EM generally is typically characteristic by the appearance of both macular and papular typical targetoid lesions (with three zones of color, as opposed to atypical targetoid lesions which have two) and papular atypical targetoid lesions, all of which are generally absent in SJS/TEN which only has macular atypical targetoid lesions [68]

Glutathione Dysregulation and the Etiology and Progression of Human Diseases

In animal studies, chronic stress can lead to structural and functional changes in some neural correlates of pain perception or pain modulation, notably in the hippocampus, which may concomitantly affect cognitive functions 2,19

Suicidal thoughts or a history of depression, as these may require close monitoring

Reduced NAT2 activity would indicate a slower acetylation process, and this gene polymorphism is more common in Caucasians than other races

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